A new class of semi-synthetic antibiotics: ferrocenyl-penicillins and -cephalosporins
1976; Elsevier BV; Volume: 107; Issue: 3 Linguagem: Inglês
10.1016/s0022-328x(00)91527-4
ISSN1872-8561
AutoresE. I. EDWARDS, R. Epton, G. Marr,
Tópico(s)Synthesis and Biological Evaluation
ResumoA series of ferrocenyl carboxylic acids has been prepared and condensed, via their acid chlorides or in the presence of N,N′-dicyclohexylcarbodiimide, with both 6-aminopenicillanic acid and 7-aminocephalosporanic acid. Almost all of the ferrocenyl-penicillins and -cephalosporins exhibited antibiotic activity, some being highly active, while others proved to be potent β-lactamase inhibitors.
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