Cassane-type Diterpenes from the Seeds of Caesalpinia minax with Their Antineoplastic Activity
2012; Thieme Medical Publishers (Germany); Volume: 78; Issue: 12 Linguagem: Inglês
10.1055/s-0032-1314976
ISSN1439-0221
AutoresGuoxu Ma, Xudong Xu, Li Cao, Jing‐Quan Yuan, Jun‐Shan Yang, Li-Yan Ma,
Tópico(s)Biological Stains and Phytochemicals
ResumoFive new cassane-type diterpenes, neocaesalpin AA ( 1 ), neocaesalpin AB ( 2 ), neocaesalpin AC ( 3 ), neocaesalpin AD ( 4 ) and neocaesalpin AE ( 5 ), were isolated from Caesalpinia minax together with three known compounds, 12 α -methoxyl,5 α ,14 β -dihydroxy-1 α ,6 α ,7 β -triacetoxycass-13(15)-en-16,12-olide ( 6 ), spirocaesalmin ( 7 ) and magnicaesalpin ( 8 ). Their structures were elucidated based on 1D and 2D NMR, MS and CD analyses. Compounds 1 – 6 were tested against Hela, HCT-8, HepG-2, MCF-7 and A549 cancer cells and showed moderate cytotoxicity with IC 50 values from 18.4 to 83.9 µM.
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