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Cytotoxic and genotoxic potential of dopamine

1999; Wiley; Volume: 55; Issue: 6 Linguagem: Inglês

10.1002/(sici)1097-4547(19990315)55

1097-4547

Alan H. Stokes, Teresa G. Hastings, Kent E. Vrana,

Nuclear Receptors and Signaling

Journal of Neuroscience ResearchVolume 55, Issue 6 p. 659-665 Mini-Review Cytotoxic and genotoxic potential of dopamine Alan H. Stokes, Alan H. Stokes Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North CarolinaSearch for more papers by this authorTeresa G. Hastings, Teresa G. Hastings Departments of Neuroscience and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PennsylvaniaSearch for more papers by this authorKent E. Vrana, Corresponding Author Kent E. Vrana [email protected] Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North CarolinaDepartment of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083.Search for more papers by this author Alan H. Stokes, Alan H. Stokes Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North CarolinaSearch for more papers by this authorTeresa G. Hastings, Teresa G. Hastings Departments of Neuroscience and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PennsylvaniaSearch for more papers by this authorKent E. Vrana, Corresponding Author Kent E. Vrana [email protected] Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North CarolinaDepartment of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083.Search for more papers by this author First published: 17 March 1999 https://doi.org/10.1002/(SICI)1097-4547(19990315)55:6 3.0.CO;2-CCitations: 352AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract A variety of in vitro and in vivo studies demonstrate that dopamine is a toxic molecule that may contribute to neurodegenerative disorders such as Parkinson's disease and ischemia-induced striatal damage. While much attention has focused on the fact that the metabolism of dopamine produces reactive oxygen species (peroxide, superoxide, and hydroxyl radical), growing evidence suggests that the neurotransmitter itself may play a direct role in the neurodegenerative process. Oxidation of the dopamine molecule produces a reactive quinone moiety that is capable of covalently modifying and damaging cellular macromolecules. This quinone formation occurs spontaneously, can be accelerated by metal ions (manganese or iron), and also arises from selected enzyme-catalyzed reactions. Macromolecular damage, combined with increased oxidant stress, may trigger cellular responses that eventually lead to cell death. Reactive quinones have long been known to represent environmental toxicants and, within the context of dopamine metabolism, may also play a role in pathological processes associated with neurodegeneration. The present discussion will review the oxidative metabolism of dopamine and describe experimental evidence suggesting that dopamine quinone may contribute to the cytotoxic and genotoxic potential of this essential neurotransmitter. J. Neurosci. Res. 55:659–665, 1999. © 1999 Wiley-Liss, Inc. Citing Literature Volume55, Issue615 March 1999Pages 659-665 RelatedInformation