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Síndrome Metabólica, seus fenótipos e resistência à insulina pelo HOMA-RI

2007; Editora da Universidade de São Paulo; Volume: 51; Issue: 9 Linguagem: Inglês

10.1590/s0004-27302007000900014

1677-9487

Ernesto Pereira de Oliveira, Maria das Dores Acioli de Lima, M. L. A. de Souza,

Public Health in Brazil

The diagnosis of the metabolic syndrome (MS) according to the National Cholesterol Education Program Adult Treatment Panel III does not reflect necessarily the presence of insulin resistance (IR), a potential therapeutical target for type 2 diabetes and cardiovascular disease prevention. Based on previous prevalence data, a cross-sectional study was conducted to determine the HOMA-IR relationship to the MS and some associated abnormalities. HOMA-IR > was higher in individuals with the MS (2.8+/-1.6 vs. 1.8+/-1.4) (p < 0.001). HOMA-IR >or= 2.5 allied good specificity and sensitivity levels for the association of MS and IR. Hyperglycemia, hypertrigliceridemia, and abdominal obesity, the MS components best related to IR, were statistically associated with HOMA-IR > 2.5, but not hypertension neither low HDL-c. The demonstration that some of MS phenotypes or associated abnormalities were more predictive for IR could point out to the possibility of the use of the index as a marker of the presence of IR associated to MS.