Produção Nacional
Revisado por pares
IS1245 genotypic analysis of Mycobacterium avium isolates from patients in Brazil
1999; Elsevier BV; Volume: 3; Issue: 4 Linguagem: Inglês
10.1016/s1201-9712(99)90023-1
ISSN1878-3511
AutoresMaria Helena Féres Saad, Leila de Souza Fonseca, Lucilaine Ferrazoli, Fátima Cristina Onofre Fandinho Montes, Moisés Palaci, Beatriz Grinsztejn, Afrânio Lineu Kritski, Angela Werneck, Natalia Poltoratskaia, Warren D. Johnson, Lee W. Riley,
Tópico(s)Bacteriophages and microbial interactions
ResumoObjective: Disseminated Mycobacterium avium infection is an emerging opportunistic disease among patients with acquired immunodeficiency syndrome (AIDS) in Brazil.The mode of transmission of M. avium in a developing country setting needs to be better characterized.Methods: Mycobacterium avium strain collections in SBo Paulo and Rio de Janeiro were analyzed according to the strains' 181245 DNA gel electrophoretic migration patterns.Medical records of the patients from whom M. avium isolates were available were reviewed, and their demographic characteristics were stratified according to the isolates' IS1245 DNA fingerprint patterns.Results: Of 105 patients, 33 (31%) with M. avium isolated between 1990 and 1994 had strains having 181245 patterns identical in patterns seen in isolates from two or more patients (designated as cluster pattern strains).Cluster pattern strains were isolated from 21 (39%) of 54 patients with disseminated infection (defined as infection due to M. avium isolated from a sterile site in an adult patient).Six of the cluster pattern strains were isolated only from sterile sites.In SBo Paulo, cluster pattern strains were significantly more likely to be isolated from patients with disseminated disease.
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