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Preparative Isolation of Destruxins from Metarhizium Anisopliae by High Performance Liquid Chromatography

1989; Marcel Dekker; Volume: 12; Issue: 3 Linguagem: Inglês

10.1080/01483918908051742

2331-0413

Sandeep Gupta, Donald W. Roberts, J. A. A. Renwick,

Insect and Arachnid Ecology and Behavior

Abstract A method has been developed for preparative isolation of destruxins, a group of major insecticidal cyclodepsipeptides from culture broth of Metarhizium anisopliae. Prepurification of the crude extract by flash chromatography on silica gel followed by HPLC on reverse phase C18 Column using linear gradients of acetonitrile-water permitted the isolation of ten destruxins.