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Epithelial-Immune Cell Interaction in Dry Eye

2008; Lippincott Williams & Wilkins; Volume: 27; Issue: Suppl 1 Linguagem: Inglês

10.1097/ico.0b013e31817f4075

1536-4798

Stephen C. Pflugfelder, Cintia S. de Paiva, De‐Quan Li, Michael E. Stern,

Corneal Surgery and Treatments

Dry eye is a potent stimulus of both innate and adaptive immune systems. At the nexus of the dry eye inflammatory/immune response is the dynamic interplay between the ocular surface epithelia and the bone marrow-derived immune cells. On the one hand, ocular surface epithelial cells play a key initiating role in this inflammatory reaction. On the other hand, they are targets of cytokines produced by activated T cells that are recruited to the ocular surface in response to dry eye. This interaction between epithelial and immune cells in dry eye will be thoroughly reviewed.