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Overview of gene structure

2006; Linguagem: Inglês

10.1895/wormbook.1.65.1

1551-8507

John Spieth,

Genetics, Aging, and Longevity in Model Organisms

Throughout the C. elegans sequencing project Genefinder was the primary protein-coding gene prediction program.These initial predictions were manually reviewed by curators as part of a "first-pass annotation" and are actively curated by WormBase staff using a variety of data and information.In the WormBase data release WS133 there are 22,227 protein-coding gene, including 2,575 alternatively-spliced forms.Twenty-eight percent of these have every base of every exon confirmed by transcription evidence while an additional 51% have some bases confirmed.Most of the genes are relatively small covering a genomic region of about 3 kb.The average gene contains 6.4 coding exons accounting for about 26% of the genome.Most exons are small and separated by small introns.The median size of exons is 123 bases, while the most common size for introns is 47 bases.Protein-coding genes are denser on the autosomes than on chromosome 1 X, and denser in the central region of the autosomes than on the arms.There are only 561 annotated pseudogenes but estimates but several estimates put this much higher.