The relationship between the monoglyceride and glycerol-3-phosphate pathways in adipose tissue
1971; Elsevier BV; Volume: 45; Issue: 1 Linguagem: Inglês
10.1016/0006-291x(71)90076-3
ISSN1090-2104
AutoresF. Michael Schultz, Mary Bob Wylie, John M. Johnston,
Tópico(s)Peroxisome Proliferator-Activated Receptors
ResumoIn addition to the glycerol-3-phosphate pathway the biosynthesis of triglycerides by the monoglyceride pathway has been described in the hamster adipose tissue. The interrelationship of the two pathways was investigated. When microsomes were utilized, the 2-monooleyl ether (0–7 mM) progressively inhibited the incorporation of 5 mM 14C-glycerol-3-phosphate into phosphatidic acid. When whole cells were employed, the synthesis of higher glycerides by the glycerol-3-phosphate pathway was similarly inhibited. The reported results provide a possible control mechanism for the biosynthesis of glyceride and, theoretically, a mechanism for the amplification of fatty acid release by this tissue.
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