Acylzirconocene Chloride as an “Unmasked” Acyl Anion: Enantioselective 1,2-Addition toα,β-Unsaturated Ketone Derivatives
1999; Wiley; Volume: 38; Issue: 16 Linguagem: Inglês
10.1002/(sici)1521-3773(19990816)38
ISSN1521-3773
AutoresYuji Hanzawa, Nobuhito Tabuchi, Kosuke Saito, Satoshi Noguchi, Takeo Taguchi,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoAngewandte Chemie International EditionVolume 38, Issue 16 p. 2395-2398 Communication Acylzirconocene Chloride as an “Unmasked” Acyl Anion: Enantioselective 1,2-Addition to α,β-Unsaturated Ketone Derivatives Yuji Hanzawa, Yuji Hanzawa [email protected] School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this authorNobuhito Tabuchi, Nobuhito Tabuchi School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this authorKosuke Saito, Kosuke Saito School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this authorSatoshi Noguchi, Satoshi Noguchi School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this authorTakeo Taguchi, Takeo Taguchi School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this author Yuji Hanzawa, Yuji Hanzawa [email protected] School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this authorNobuhito Tabuchi, Nobuhito Tabuchi School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this authorKosuke Saito, Kosuke Saito School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this authorSatoshi Noguchi, Satoshi Noguchi School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this authorTakeo Taguchi, Takeo Taguchi School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan, Fax: (+81) 426-76-3257Search for more papers by this author First published: 06 August 1999 https://doi.org/10.1002/(SICI)1521-3773(19990816)38:16 3.0.CO;2-WCitations: 28AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The chiral monodentate phosphane ligand (R)-MOP facilitated the first enantioselective nucleophilic 1,2-addition of an “unmasked” acyl anion to a carbonyl group in the PdII-catalyzed reaction of α,β-unsaturated ketones with acylzirconocene chlorides [Eq. (1), 66 % ee, 88 % yield; (R)-MOP=(R)-2-(diphenylphosphanyl)-2′-methoxy-1,1′-binaphthyl]. Citing Literature Volume38, Issue16August 16, 1999Pages 2395-2398 RelatedInformation
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