Langerhans cells, nitric oxide, keratinocytes and psoriasis
1999; Elsevier BV; Volume: 20; Issue: 6 Linguagem: Inglês
10.1016/s0167-5699(98)01411-x
ISSN1355-8242
AutoresVictoria Kolb-Bachofen, D. Bruch‐Gerharz,
Tópico(s)Ocular Surface and Contact Lens
ResumoIn a recent Viewpoint article, Morhenn gave a provocative view on the role of Langerhans cells expressing inducible nitric oxide synthase (iNOS) in the pathogenesis of psoriasis 1 Morhenn V.B. Immunol. Today. 1997; 18: 433-436 Abstract Full Text PDF PubMed Scopus (53) Google Scholar . It is not surprising that this article raised an argument 2 McKenzie R.C. Weller R. Immunol. Today. 1998; 19: 427 Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar because there is no direct proof for the postulated key role of iNOS-expressing Langerhans cells in this immune-mediated skin disease, whereas numerous studies demonstrate beyond doubt that epidermal keratinocytes play a key role 3 Bruch-Gerharz D. Ruzicka T. Kolb-Bachofen V. J. Invest. Dermatol. 1998; 110: 1-7 Crossref PubMed Scopus (197) Google Scholar .
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