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Genome sequence and analysis of the tuber crop potato

2011; Nature Portfolio; Volume: 475; Issue: 7355 Linguagem: Inglês

10.1038/nature10158

1476-4687

Xun Xu, Pan S, Shifeng Cheng, Bo Zhang, Mu D, Ni P, Guojie Zhang, S. Yang, Ran Li, Jian Wang, Gisella Orjeda, Frank Guzmán, Manuel Muñoz‐Torres, Roberto Lozano, Olga Ponce, D Martinez, De la Cruz G, S. K. Chakrabarti, VU Patil, Skryabin Kg, Kuznetsov Bb, Nikolai V. Ravin, Kolganova Tv, Alexey V. Beletsky, Andrey V. Mardanov, Alex Di Genova, Dan Bolser, David Martin, Li G, H. J. Yang, Hanhui Kuang, Qinggang Hu, Xingyao Xiong, Bishop Gj, Boris Sagredo, Natalia Mejía, W. Zagórski, Robert Gromadka, Jan Gawor, Paweł Szczęsny, Sanwen Huang, Zhonghua Zhang, Chujun Liang, Jun He, Yun Li, Yayi He, Juan Xu, Youjun Zhang, Bin-Bin Xie, Yuan Du, Di Qu, Merideth Bonierbale, Marc Ghislain, Herrera Mdel R, Giovanni Giuliano, Marco Pietrella, Gaetano Perrotta, Paolo Facella, Katherine L. O’Brien, Sérgio Enrique Feingold, Barreiro Le, Massa Ga, Luis Diambra, Brett R. Whitty, Brieanne Vaillancourt, Honghui Lin, M. An, M Geoffroy, Steven S. Lundback, Dean DellaPenna, C. Robin Buell, Sharma Sk, David Marshall, Robbie Waugh, Glenn J. Bryan, M. Destefanis, István Nagy, Dan Milbourne, Susan Thomson, Mark Fiers, Jeanne M. E. Jacobs, Nielsen Kl, Mads Sønderkær, Marina Iovene, Giovana Augusta Torres, Jing Jiang, Veilleux Re, C. Bachem, Jan de Boer, Theo Borm, B. Kloosterman, Herman J. van Eck, Erwin Datema, Hekkert Bt, Aska Goverse, van Ham Rc, Visser Rg,

Chromosomal and Genetic Variations

Potato (Solanum tuberosum L.) is the world’s most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop. The genome of the potato (Solanum tuberosum L.), a staple crop vital to food security, has been sequenced. The Potato Genome Sequencing Consortium sequenced a homozygous doubled-monoploid potato clone as well as a heterozygous diploid clone. Genome analysis reveals traces of at least two genome duplication events and genes specific to Asterids, a large clade of flowering plants of which the potato is the first to be sequenced. Gene presence/absence variants and other potentially deleterious mutations are frequent and may be the cause of inbreeding depression. The genome sequence will facilitate genetic improvements in the potato with a view to improving yield and to increasing disease and stress resistance of this crop, which is a now a significant component of worldwide food production and is becoming increasingly important in the developing world.