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Revisão Produção Nacional
BIBTEX RIS

Limb anomalies following chorionic villus sampling: A registry based case‐control study

1992; Wiley; Volume: 44; Issue: 6 Linguagem: Inglês

10.1002/ajmg.1320440639

ISSN

1096-8628

Autores

Pierpaolo Mastroiacovo, Lorenzo D. Botto, Denise P. Cavalcanti, Faustina Lalatta, Angelo Selicorni, Alberto Eugenio Tozzi, Dante Baronciani, Anna Chiara Cigolotti, Sergio Giordano, Fabio Petroni, Francesco Puppin,

Tópico(s)

Congenital limb and hand anomalies

Resumo

Abstract Using data from the Italian Multicentric Birth Defect Registry a case–control study was performed to verify if chorionic villus sampling (CVS) was associated with transverse limb defects (TLD), with or without features of oro–mandibular–limb hypogenesis complex (OMLHC), in the exposed offspring. The results show that the risk of TLD and OMLHC is increased following CVS, and is particularly high for CVS performed early in pregnancy, i.e., under 70 days of gestational age. These results, together with a review of other epidemiologic studies, biological data and clinical reports, strongly suggest a causative role of CVS as a risk factor for TLD and indicate that at this stage CVS before 70 days of gestational age should be discouraged as an option for prenatal diagnosis and that all patients wishing to undergo CVS should be informed about the possible risk of the procedure. © 1992 Wiley‐Liss, Inc.

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