Portal de Periódicos da CAPES

Vertebrate intestinal endoderm development

2011; Wiley; Volume: 240; Issue: 3 Linguagem: Inglês

10.1002/dvdy.22540

1097-0177

Jason R. Spence, Ryan Lauf, Noah F. Shroyer,

Digestive system and related health

The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as associated organs. To generate a functional intestine, a series of highly orchestrated developmental processes must occur. In this review, we attempt to cover major events during intestinal development from gastrulation to birth, including endoderm formation, gut tube growth and patterning, intestinal morphogenesis, epithelial reorganization, villus emergence, as well as proliferation and cytodifferentiation. Our discussion includes morphological and anatomical changes during intestinal development as well as molecular mechanisms regulating these processes.