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Databases in the area of pharmacogenetics

2011; Wiley; Volume: 32; Issue: 5 Linguagem: Inglês

10.1002/humu.21454

1098-1004

Sarah C. Sim, Russ B. Altman, Magnus Ingelman‐Sundberg,

Computational Drug Discovery Methods

In the area of pharmacogenetics and personalized health care it is obvious that databases, providing important information of the occurrence and consequences of variant genes encoding drug metabolizing enzymes, drug transporters, drug targets, and other proteins of importance for drug response or toxicity, are of critical value for scientists, physicians, and industry. The primary outcome of the pharmacogenomic field is the identification of biomarkers that can predict drug toxicity and drug response, thereby individualizing and improving drug treatment of patients. The drug in question and the polymorphic gene exerting the impact are the main issues to be searched for in the databases. Here, we review the databases that provide useful information in this respect, of benefit for the development of the pharmacogenomic field.