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The Effects of Enteric Coating of Aspirin Tablets on Occult Gastrointestinal Blood Loss

1977; Wiley; Volume: 7; Issue: 6 Linguagem: Inglês

10.1111/j.1445-5994.1977.tb02315.x

0004-8291

Graydon Howe, G. David Champion, A. B. Corrigan, John Hewson, Anika Haski, Richard O. Day, Phillip Paull, Garry G. Graham,

Heparin-Induced Thrombocytopenia and Thrombosis

Australian and New Zealand Journal of MedicineVolume 7, Issue 6 p. 600-604 The Effects of Enteric Coating of Aspirin Tablets on Occult Gastrointestinal Blood Loss G. B. Howe, G. B. Howe Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW *Medical Megistrar, Kepatriation ijeneral Hospital, Concord.Search for more papers by this authorG. D. Champion, Corresponding Author G. D. Champion Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW †Visitmg Physician, RGH Concord, Honorary Physician in Rheumatology, St. Vincent's Hospital.Honorary Physician in Rheumatology, St. Vincent's Hospital, Darlinghurst, NSW 2010, Australia Accepted for publication: 19 July, 1977Search for more papers by this authorA. B. Corrigan, A. B. Corrigan Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW ‡Visiting Consultant Physician in Rheumatology, Repatriation General Hospital, Concord.Search for more papers by this authorJ. Hewson, J. Hewson Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW **Specialist (Haematology), Repatriation General Hospital, Concord.Search for more papers by this authorA. Haski, A. Haski Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW ††Honorary Clinical Assistant in Rheumatology, St. Vincent's Hospital, Sydney.Search for more papers by this authorR. O. Day, R. O. Day Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW ‡‡NH and MRC Research Fellow, Department of Clinical Pharmacology, St. Vincent's Hospital, Sydney.Search for more papers by this authorP. D. Paull, P. D. Paull Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW ***Scientific Officer, Department of Clinical Pharmacology, St. Vincent's Hospital, Sydney.Search for more papers by this authorG. G. Graham, G. G. Graham Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW †††Senior Scientific Officer, Department of Clinical Pharmacology, St. Vincent's Hospital, Sydney.Search for more papers by this author G. B. Howe, G. B. Howe Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW *Medical Megistrar, Kepatriation ijeneral Hospital, Concord.Search for more papers by this authorG. D. Champion, Corresponding Author G. D. Champion Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW †Visitmg Physician, RGH Concord, Honorary Physician in Rheumatology, St. Vincent's Hospital.Honorary Physician in Rheumatology, St. Vincent's Hospital, Darlinghurst, NSW 2010, Australia Accepted for publication: 19 July, 1977Search for more papers by this authorA. B. Corrigan, A. B. Corrigan Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW ‡Visiting Consultant Physician in Rheumatology, Repatriation General Hospital, Concord.Search for more papers by this authorJ. Hewson, J. Hewson Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW **Specialist (Haematology), Repatriation General Hospital, Concord.Search for more papers by this authorA. Haski, A. Haski Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW ††Honorary Clinical Assistant in Rheumatology, St. Vincent's Hospital, Sydney.Search for more papers by this authorR. O. Day, R. O. Day Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW ‡‡NH and MRC Research Fellow, Department of Clinical Pharmacology, St. Vincent's Hospital, Sydney.Search for more papers by this authorP. D. Paull, P. D. Paull Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW ***Scientific Officer, Department of Clinical Pharmacology, St. Vincent's Hospital, Sydney.Search for more papers by this authorG. G. Graham, G. G. Graham Departments of Haematology and Rheumatology, Repatriation General Hospital, Concord, and Departments of Clinical Pharmacology and Rheumatology, St. Vincent's Hospital, Sydney, NSW †††Senior Scientific Officer, Department of Clinical Pharmacology, St. Vincent's Hospital, Sydney.Search for more papers by this author First published: December 1977 https://doi.org/10.1111/j.1445-5994.1977.tb02315.xCitations: 12 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary The effects of enteric coating of aspirin tablets on occult gastrointestinal blood loss. The effect of enteric coating of aspirin tablets on the gastrointestinal blood loss associated with high dose aspirin therapy was investigated in 12 patients with rheumatoid arthritis. Occult blood loss was measured after labelling the patients' red blood cells with Cr 51. Three salicylate preparations were used: enteric coated tablets of aspirin ("Rhusal", G.P, Laboratories, 7 × 650 mg per day), uncoated tablet cores of aspirin from the same batch (7×650 mg per day) and enteric coated tablets of sodium salicylate (7 × 600 mg and 1 × 300 mg per day). Daily blood loss during a salicylate-free period was (0.7±0.15ml, mean±SE). Blood loss was significantly increased during dosage with all three salicylate preparations. Daily blood loss during dosage with the uncoated tablets of aspirin (5.3 ± 0.3 ml) was significantly greater than during dosage with the enteric coated tablets of aspirin (2.3 ± 0.3 ml) and enteric coated tablets of sodium salicylate (2.1 ± 0.4 ml). The bioavailability of the salicylate preparations was studied in seven of the 12 patients. Mean plasma salicylate concentration two hours after the second daily dose during dosage with the enteric coated tablets of aspirin was 118±15 μg/ml compared to 131 ± 16 μg/ml during dosage with the uncoated tablets. Urinary recoveries of the daily dosage of aspirin in the two formulations were also similar. References 1 Champion, G. D., Day, R. O., Graham, G. G. and Paull, P. D. (1975): Salicylates in rheumatoid arthritis, in Clm Rheum. Dis. 1, 2, Eds. C. Pearson and W. Carson Dick, W B. Saunders, London , p. 245. 2 Pierson, R. N., Holt, P. R., Watson, R. M. and Keating, R. P. (1961): Aspirin and gastrointestinal bleeding. Chromate51 blood loss studies, Amer. J. Med. 31, 259. 3 Scott, J. T., Porter, I. H., Lewis, S.M. and Dixon, A St. J. (1961) Studies of gastrointestinal bleeding caused by corticosteroids, salicylates and other analgesics, Quart, J. Med.. 4 Grossman, M. I., Matsumoto, K. K. and Lichter, R. J. (1960) Fecal blood loss produced by oral and intravenous administration of various salicylates. Gastroenterology 40, 3, 383. 5 Lange, H F. (1957): Salicylates and Gastric Haemorrhage In Occult Bleeding, Gastroenterology 33, 770. 6 Day, R. O., Pauil, P. D., Champion, G. D. and Graham, G. G. (1975) Evaluation of an enteric coated aspirin preparation, Aitu. N.Z J. Med 6, 45. 7 Goulston, K. and Skyring, A. (1964): Effect of paracetamol (n-acetyl-O-aminophenol) on gastrointestinal bleeding. Gut 5, 463. 8 Wood, P. H N., Harvey-Smith, E. A. and Dixon, A. St. J. (1962). Salicylates and gastrointestinal bleeding. Acetylsalicyhc acid and aspirin derivatives, Brit. med J. 1, 669. 9 Edmonds, J. (1977). 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Aspirin: Intestinal damage in rats. Science 170, 183. 18 Levin, E., Kirshner. J. B., Palmer, W. O. and Butier, C. (1948): The variability and periodicity of the nocturnal gastric secretion in normal individuals, Gastroenterology 10, 959. 19 Grant, R. (1951): The cytolytic action of some gastro intestinal secretion and enzymes on epithelial cells of the gastric and duodenal mucosa, J. cell camp. Physiol 37, 137. 20 Stubbé, L. Th. F. L., Petersen, J. H. and Van Heulen, C., (1962). Aspirir preparations and their noxious effect on the gastro-intestinal tract, Brit, med J. 1, 675. 21 Goulston, K. R. and Cooke, A. R. (1968) Alcohol, aspirin and gastro intestinal bleeding, Brit. med. J. 4, 664. 22 Needham, C. A., Kyle, J., Jones, P F., Johnson, S. J. and Kerridge, D F. (1971): Aspirin and alcohol in gastro-intestinal damage, Gut 12, 819. 23 Bouchier, J. A. D. and Williams, H. S. (1969) Determination of faecal blood-loss after combined alcohol and sodium acetylsal icy late intake, Lancet 1, 178. 24 Lfvy, G. and Tsuchiya, G. (1972): Salicylate accumulation kinetics m man. New Engl J. Med. 287, 430. 25 Graham, G. G., Champion, G. D., Day, R. O. and Paull, P. D. (1977) Patterns of plasma concentrations and urinary excretion of salicylate in patients with rheumatoid arthritis, Clin. Pharmacol. Ther. in press. Citing Literature Volume7, Issue6December 1977Pages 600-604 ReferencesRelatedInformation