A new cyclopeptide metabolite of marine gut fungus from Ligia oceanica
2014; Taylor & Francis; Volume: 28; Issue: 13 Linguagem: Inglês
10.1080/14786419.2014.902945
ISSN1478-6427
AutoresJinzhong Xu, Shizhe Zhao, Xian‐Wen Yang,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoA new cyclopeptide, together with three known amino acid derivatives, was isolated from marine-derived fungus Aspergillus flavipes, which was found in the gut of isopod Ligia oceanica. The novel peptide contains four amino acid units, proline, 5-methoxyanthranilic acid, isoleucine and 3-aminoacrylic acid. Its structure was determined on the basis of NMR, HR-MS and MSn spectral data analysis. The two unusual amino acid residues, 5-methoxyanthranilic acid and 3-aminoacrylic acid, were first found in natural product. The known compound N-benzoyl-phenylalanine methyl ester was first found as fungal metabolite. This is the first report of natural products isolated from marine gut fungi.
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