A compound arterial prosthesis: the importance of the sterilization procedure on the healing and stability of albuminated polyester grafts
1985; Elsevier BV; Volume: 6; Issue: 2 Linguagem: Inglês
10.1016/0142-9612(85)90075-4
ISSN1878-5905
AutoresRobert Guidoin, Roger Snyder, Martin W. King, L. Martin, KM Botzko, John Awad, M Marois, Clément Gosselin,
Tópico(s)Reconstructive Surgery and Microvascular Techniques
ResumoIn response to the demand for a vascular prosthesis which achieves reliable haemostasis without preclotting, a new compound albumin/polyester prosthesis has been developed. In order to optimize the sterilization procedures for this device, two series of implantations in the thoracic aorta of dogs were undertaken to compare the effects of ethylene oxide (EtO) and gamma-radiation. Preclotted polyester prostheses were implanted in two additional control series. Pathological analysis of the explanted grafts indicated that gamma-radiation is to be preferred over EtO because it results in faster rates of healing. While the albumin coating delayed the thrombotic response and fibrinolytic activity, the extent of healing of the radiation sterilized graft was equivalent to that achieved by preclotted polyester prostheses in the medium and long term. Measurements of the strength and dimensional changes of the graft demonstrated that, in addition to reducing the risks of acute thrombosis and postoperative haemorrhage, the albumin coating improves the dimensional stability of the knitted structure.
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