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Altered Corticostriatal Functional Connectivity in Obsessive-compulsive Disorder

2009; American Medical Association; Volume: 66; Issue: 11 Linguagem: Inglês

10.1001/archgenpsychiatry.2009.152

1538-3636

Ben J. Harrison, Carles Soriano‐Mas, Jesús Pujol, Héctor Ortiz, Marina López‐Solà, Rosa Hernández‐Ribas, Joan Deus, Pino Alonso, Murat Yücel, Christos Pantelis, José M. Menchón, Narcı́s Cardoner,

Psychosomatic Disorders and Their Treatments

Context: Neurobiological models of obsessive-compulsive disorder (OCD) emphasize disturbances in the function and connectivity of brain corticostriatal networks, or "loops."Although neuroimaging studies of patients have supported this network model of OCD, very few have applied measurements that are sensitive to brain connectivity features.Objective: Using resting-state functional magnetic resonance imaging, we tested the hypothesis that OCD is associated with disturbances in the functional connectivity of primarily ventral corticostriatal regions, measured from coherent spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) signal.Design: Case-control cross-sectional study.Setting: Hospital referral OCD unit and magnetic resonance imaging facility.Participants: A total of 21 patients with OCD (10 men, 11 women) and 21 healthy control subjects matched for age, sex, and estimated intelligence.