Portal de Periódicos da CAPES

Multiple Hamartoma Syndrome (Cowden's Disease) Associated With Non-Hodgkin's Lymphoma

1986; American Medical Association; Volume: 122; Issue: 5 Linguagem: Inglês

10.1001/archderm.1986.01660170102029

1538-3652

Dirk M. Elston,

Hedgehog Signaling Pathway Studies

A 70-year-old woman with the multiple hamartoma syndrome is described. Diagnosis was based on the clinical presentation and histopathologic examination of cutaneous trichilemmomas. The case is reported to document the association of Cowden's disease with non-Hodgkin's lymphoma. This is the first known report of the occurrence of trichilemmomas in the sacral area. The literature concerning the association of the multiple hamartoma syndrome with malignancy is reviewed.