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Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin

2005; Wiley; Volume: 22; Issue: 9 Linguagem: Inglês

10.1111/j.1365-2036.2005.02649.x

1365-2036

Neville D. Yeomans, Angel I. Lanas, Nicholas J. Talley, A. B. R. Thomson, Rahim Daneshjoo, Birgitta Eriksson, S. Appelman-Eszczuk, Goran Långström, J. Næsdal, Pedro Serrano, Mohan Singh, M. M. Skelly, C J Hawkey,

Helicobacter pylori-related gastroenterology studies

Summary Background : Aspirin is valuable for preventing vascular events, but information about ulcer frequency is necessary to inform risk‐benefit decisions in individual patients. Aim : To determine ulcer prevalence and incidence in a population representative of those given aspirin therapy and evaluate risk predictors. Methods : Patients taking aspirin 75–325 mg daily were recruited from four countries. Exclusions included use of gastroprotectant drugs or other non‐steroidal anti‐inflammatory drugs. We measured point prevalence of endoscopic ulcers, after quantitating dyspeptic symptoms. Incidence was assessed 3 months later in those eligible to continue (no baseline ulcer or reason for gastroprotectants). Results : In 187 patients, ulcer prevalence was 11% [95% confidence interval (CI) 6.3–15.1%]. Only 20% had dyspeptic symptoms, not significantly different from patients without ulcer. Ulcer incidence in 113 patients followed for 3 months was 7% (95% CI 2.4–11.8%). Helicobacter pylori infection increased the risk of a duodenal ulcer [odds ratio (OR) 18.5, 95% CI 2.3–149.4], as did age >70 for ulcers in stomach and duodenum combined (OR 3.3, 95% CI 1.3–8.7). Conclusions : Gastroduodenal ulcers are found in one in 10 patients taking low‐dose aspirin, and most are asymptomatic; this needs considering when discussing risks/benefits with patients. Risk factors include older age and H. pylori (for duodenal ulcer).