Multicentric pleomorphic xanthoastrocytoma in a patient with neurofibromatosis Type 1
2005; American Association of Neurological Surgeons; Volume: 102; Issue: 2 Linguagem: Inglês
10.3171/jns.2005.102.2.0376
ISSN1933-0693
AutoresStéphan Saïkali, Anne Le Strat, Anne Heckly, Nathalie Stock, Jean‐Marie Scarabin, Abderrahmane Hamlat,
Tópico(s)Vascular Malformations Diagnosis and Treatment
Resumo✓ The authors report an unusual case of multicentric pleomorphic xanthoastrocytoma (PXA) in a 36-year-old woman with neurofibromatosis Type 1 (NF1). Both lesions were diagnosed as PXA but demonstrated different neuroimaging features and very different outcomes. Although the occipital lesion was cured surgically, the cerebellar tumor recurred three times and underwent malignant transformation into an anaplastic oligodendroglioma. The authors discuss the causes of PXA and suggest that it could originate from common bipotential precursor cells with two phenotypes.
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