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Synthesis of New Chiral Monodentate Phosphite Ligands and Their Use in Catalytic Asymmetric Hydrogenation

2003; American Chemical Society; Volume: 5; Issue: 21 Linguagem: Inglês

10.1021/ol035343r

1523-7060

Zihao Hua, Victor C. Vassar, Iwao Ojima,

Axial and Atropisomeric Chirality Synthesis

[reaction: see text] New monodentate phosphite ligands have been developed from axially chiral biphenols, which show excellent enantioselectivity in the Rh(I)-catalyzed hydrogenation of dimethyl itaconate. The new chiral ligand system is suitable to create libraries and possesses fine-tuning capability.