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Immobilized microorganisms in the reduction of ethyl benzoylacetate

2009; Elsevier BV; Volume: 50; Issue: 52 Linguagem: Inglês

10.1016/j.tetlet.2009.10.068

1873-3581

Aline de Souza Ramos, Joyce Benzaquem Ribeiro, Leonardo Vázquez, Sorele Batista Fiaux, Selma Gomes Ferreira Leite, Maria da Conceição Klaus V. Ramos, Francisco Radler de Aquino Neto, Octávio Augusto Ceva Antunes,

Amino Acid Enzymes and Metabolism

The enantioselective reduction of ethyl benzoylacetate (EBA) into ethyl (S)-3-hydroxy-3-phenylpropanoate (S-HPPE) by nine yeast strains and three filamentous fungi strains is described. The conversion obtained was in the range 0–89% and the enantiomeric excess was 100% in many cases. Conversion levels were higher when the reduction was performed with microorganisms immobilized in calcium alginate and enantioselectivity remained excellent. Some reaction’s conditions of bioreduction by immobilized cells of Rhodotorula rubra were studied using a 25-2 fractional factorial design.