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Singlet Oxygen Generation from Water-Soluble Quantum Dot−Organic Dye Nanocomposites

2006; American Chemical Society; Volume: 128; Issue: 19 Linguagem: Inglês

10.1021/ja057959c

1943-2984

Lixin Shi, Billy Hernandez, Matthias Selke,

Nanoplatforms for cancer theranostics

Water-soluble quantum dot−organic dye nanocomposites have been prepared via electrostatic interaction. We used CdTe quantum dots with diameters up to 3.4 nm, 2-aminoethanethiol as a stabilizer, and meso-tetra(4-sulfonatophenyl)porphine dihydrochloride (TSPP) as an organic dye. The photophysical properties of the nanocomposite have been investigated. The fluorescence of the parent CdTe quantum dot is largely suppressed. Instead, indirect excitation of the TSPP moiety leads to production of singlet oxygen with a quantum yield of 0.43. The nanocomposite is sufficiently photostable for biological applications.