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Early Chronic Low-Level Methylmercury Poisoning in Monkeys Impairs Spatial Vision

1982; American Association for the Advancement of Science; Volume: 216; Issue: 4547 Linguagem: Inglês

10.1126/science.7079739

1095-9203

Deborah C. Rice, Steven G. Gilbert,

Retinal Development and Disorders

Five monkeys were treated from birth with oral doses of mercury as methylmercury (50 micrograms per kilogram of body weight per day); concentrations in the blood peaked at 1.2 to 1.4 parts per million; and declined after weaning from infant formula to a steady level of 0.6 to 0.9 part per million. There were no overt signs of toxicity. When tested between 3 and 4 years of age under conditions of both high and low luminance, treated monkeys exhibited spatial vision that was impaired compared with that of control monkeys.