Studies on Cephalosporin-C production using immobilised cells of Cephalosporium acremonium in a packed bed reactor
1992; Elsevier BV; Volume: 27; Issue: 6 Linguagem: Inglês
10.1016/0032-9592(92)87013-7
ISSN1873-3298
AutoresSubir Kundu, Amulya Chandra Mahapatra, Pradeep Srivastava, Kanika Kundu,
Tópico(s)Pharmaceutical and Antibiotic Environmental Impacts
ResumoThe production of the β-lactam antibiotic, Cephalosporin-C in a packed bed bioreactor was studied using Cephalosporium acremonium immobilised in calcium alginate, bagasse, and silk sachets. The specific β-lactam antibiotic production rate of immobilised cells was about 120%, 125% and 133% at 100 h (free cells 100%) for calcium alginate, bagasse and silk sachets, respectively. A cells-to-carrier ratio of 3:2 was found to be optimum throughout these studies. The effect of recycle ratio indicated diffusion barriers to substrate transport.
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