Thiolysis as an activation process in N-sulfenylated derivatives of methylcarbamate esters
1975; Elsevier BV; Volume: 5; Issue: 4 Linguagem: Inglês
10.1016/0048-3575(75)90056-5
ISSN1095-9939
AutoresY.C. Chiu, A. L. Black, T. R. Fukuto,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoAn activation process involving thiolytic cleavage of the NS bond in several N-sulfenylated-N-methylcarbamates was shown to be a nonenzymatic reaction. Biological tissues, including subcellular fractions of mouse liver; heat-denatured microsomal enzyme, mouse blood, commercial protein, and housefly homogenate, as well as thiol reagents, readily effected the cleavage of the NS bond. The inhibitory effect of sulfhydryl inhibitors such as N-methylmaleimide and p-chloromercuribenzoate in the incubation system suggests that thiol residues in biological tissue are involved in this thiolytic reaction. Results from kinetic and product analysis also support this conclusion.
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