Portal de Periódicos da CAPES

Antimicrobial Activity and Cytotoxicity of Bis(indole) Alkaloids from the Sponge Spongosorites sp.

2006; Pharmaceutical Society of Japan; Volume: 29; Issue: 3 Linguagem: Inglês

10.1248/bpb.29.570

1347-5215

Ki‐Bong Oh, Woongchon Mar, Sanghee Kim, Ji-Yun Kim, Tae‐Hoon Lee, Jae-Gyu Kim, Dae-Hyun Shin, Chung Ja Sim, Jongheon Shin,

Microbial Natural Products and Biosynthesis

Bis(indole) alkaloids, of the topsentin class (1—4) and hamacanthin class (5—9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited more potent antibacterial activity than those of the topsentin class. Deoxytopsentin (1) and hamacanthin A (5) also exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus, with MIC values of less than 12.5 μg/ml. In the antifungal activity test, hamacanthins, especially hamacanthin A (5), showed potent inhibitory activity against medically important pathogenic fungi. In contrast, all of the topsentins (1—4) were inactive against fungal growth. These compounds (1—9) also exhibited moderate cytotoxicity against cancer cell lines at concentrations between 1.1 and >20 μg/ml.