Molecular diagnosis and monitoring of leukemia and lymphoma
1993; Elsevier BV; Volume: 17; Issue: 12 Linguagem: Inglês
10.1016/0145-2126(93)90166-i
ISSN1873-5835
AutoresErnest C. Borden, Jill Waalen, Anna Marina Liberati, Fausto Grignani,
Tópico(s)Acute Myeloid Leukemia Research
ResumoThe field of molecular epidemiology, using modern epidemiological approaches and taking the advantage of the advances in molecular biology can provide new tools for the exploration of etiological determinants, either environmental or hereditary, in the development of hematological neoplasms. It is now possible to identify some host susceptibility characteristics, to measure the effective dose of exposure, and to identify early, pre-clinical biological effects, using sensitive and specific biomarkers. The significant variation in the incidence of hematological neoplasms in different geographical areas, races, and age groups, the high rates of familial aggregation in certain populations, the involvement of protooncogenes and tumor suppressor genes in the development of hematological neoplasms, as well as of many environmental agents such as chemicals, radiation, and viruses, support the important role of molecular epidemiology in the investigation of the development of hematological neoplasms.
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