Alterations in Fluid, Electrolyte and Energy Balance in Rats with Median Eminence Lesions
1966; Oxford University Press; Volume: 79; Issue: 2 Linguagem: Inglês
10.1210/endo-79-2-301
ISSN1945-7170
AutoresMadeline M. Fusco, Richard L. Malvin, Paul C. Churchill,
Tópico(s)Electrolyte and hormonal disorders
ResumoMetabolic balance studies were made on rats with permanent diabetes insipidus produced by placing electrolytic lesions in the median eminence of the tuber cinereum. Daily water, food, Na and K intakes, urine volume and osmolality, and Na and K excretion were measured for periods up to 6 months. Following lesion, the rats showed the characteristic signs of diabetes insipidus, i.e., polyuria and polydipsia. Among the additional observations made in this study, 3 were most striking. 1) Food intake increased significantly above the control value. This increased food consumption was due in part to the marked increase in water exchange. 2) Although these rats continuously excreted hypotonic urine, when challenged by water deprivation, they were able to concentrate their urine to nearly control levels. 3) These animals altered water intake and urine volume, but not urine osmolality, when deprived of food or fed sucrose. This is in contrast to control rats, which showed marked reductions in urine osmolality and no change in water intake or urine volume. (Endocrinology79: 301, 1966)
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