Human-Leukocyte Antigen Class I Cw 1502 and Class II DR 0301 Genotypes Are Associated with Resistance to Severe Acute Respiratory Syndrome (SARS) Infection
2011; Mary Ann Liebert, Inc.; Volume: 24; Issue: 5 Linguagem: Inglês
10.1089/vim.2011.0024
ISSN1557-8976
AutoresSheng‐Fan Wang, Kuan-Hsuan Chen, Marcelo Chen, Wen-Yi Li, Yen‐Ju Chen, Ching-Han Tsao, Muh‐Yong Yen, Jason C. Huang, Yi‐Ming Arthur Chen,
Tópico(s)COVID-19 Clinical Research Studies
ResumoOne-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3 y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).
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