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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Synthesis and Antileishmanial Activity of Lipidic Amino Alcohols

2009; Wiley; Volume: 75; Issue: 2 Linguagem: Inglês

10.1111/j.1747-0285.2009.00923.x

ISSN

1747-0285

Autores

Elaine Soares Coimbra, Mauro V. de Almeida, Celso de Oliveira Rezende Júnior, Aline F. Taveira, Cristiane França da Costa, Ana Cristina de Almeida, Elaine F. C. Reis, Vânia Lúcia da Silva,

Tópico(s)

Trypanosoma species research and implications

Resumo

In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC(50) below 10 microm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.

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