Antiproliferative Activity of Withanolides against Human Breast Cancer Cell Lines
2010; American Chemical Society; Volume: 73; Issue: 5 Linguagem: Inglês
10.1021/np9006734
ISSN1520-6025
AutoresRubén P. Machín, Adriana S. Veleiro, Viviana E. Nicotra, Juan C. Oberti, José M. Padrón,
Tópico(s)Computational Drug Discovery Methods
ResumoThe in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 muM. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.
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