Dopamine receptor antagonists inhibit the natriuretic response to atrial natriuretic factor (ANF)
1985; Elsevier BV; Volume: 36; Issue: 22 Linguagem: Inglês
10.1016/0024-3205(85)90314-5
ISSN1879-0631
AutoresM. Marin-Grez, Josephine P. Briggs, G Schubert, J. Schnermann,
Tópico(s)Heart Failure Treatment and Management
ResumoThe diuretic and natriuretic response of anesthetized rats to low doses of semi-purified atrial extracts or synthetic α-hANP was completely blocked by intravenous injection of 50 μg of haloperidol or chlorpromazine. Sulpiride or metoclopramide at the same doses did not show this effect. We conclude from these results that dopamine receptors, probably of the D1-type, are involved in the natriuretic effect of the atrial peptides.
Referência(s)