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Bactericidal Activity of 5 Beta-Lactam Antibiotics Against Streptococcus Pneumoniae

1997; Elsevier BV; Volume: 3; Issue: 3 Linguagem: Inglês

10.1007/bf02491504

1437-7780

Juan Carlos Rodrı́guez, P. Ruiz de Loizaga, Maite Celdrán, Gloria Royo,

Antibiotic Use and Resistance

Assays were performed to determine bactericidal activity as a function of time (1, 3, 5, and 7 hours) and of the concentration (1, 2, 4, and 8 MIC) of antibiotics for 2 penicillin-sensitive strains ofStreptococcus pneumoniae (MIC<0.06 mg/L), 2 strains with moderate penicillin sensitivity (MIC=0.125 mg/L) and 2 penicillin-resistant strains (MIC-2 mg/L). The beta-lactam antibiotics studied were penicillin, amoxicillin, cefotaxime, imipenem and cefpirome. Imipenem was the antibiotic with the greatest antibacterial activity, followed by amoxicillin. The bactericidal activity of all the antibiotics was greater against the penicillin-sensitive strains than against those strains with some degree of resistance. However, the bactericidal activity observed for cefpirome suggests that further studies are necessary to determine the value of this antibiotic in the treatment of severeS. pneumoniae infections. Assays were performed to determine bactericidal activity as a function of time (1, 3, 5, and 7 hours) and of the concentration (1, 2, 4, and 8 MIC) of antibiotics for 2 penicillin-sensitive strains ofStreptococcus pneumoniae (MIC<0.06 mg/L), 2 strains with moderate penicillin sensitivity (MIC=0.125 mg/L) and 2 penicillin-resistant strains (MIC-2 mg/L). The beta-lactam antibiotics studied were penicillin, amoxicillin, cefotaxime, imipenem and cefpirome. Imipenem was the antibiotic with the greatest antibacterial activity, followed by amoxicillin. The bactericidal activity of all the antibiotics was greater against the penicillin-sensitive strains than against those strains with some degree of resistance. However, the bactericidal activity observed for cefpirome suggests that further studies are necessary to determine the value of this antibiotic in the treatment of severeS. pneumoniae infections.