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Sprouty and cancer: The first terms report

2006; Elsevier BV; Volume: 242; Issue: 2 Linguagem: Inglês

10.1016/j.canlet.2005.12.032

1872-7980

Ting Ling Lo, Chee Wai Fong, Permeen Yusoff, Arthur B. McKie, Mei‐Sze Chua, Hing Y. Leung, Graeme R. Guy,

PI3K/AKT/mTOR signaling in cancer

The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors.