Antitussive Effects of L -Ephedrine, Amygdalin, and Makyokansekito (Chinese Traditional Medicine) using a Cough Model Induced by Sulfur Dioxide Gas in Mice
1986; Thieme Medical Publishers (Germany); Volume: 52; Issue: 04 Linguagem: Inglês
10.1055/s-2007-969151
ISSN1439-0221
AutoresMasanori Miyagoshi, Sakae Amagaya, Yukio Ogihara,
Tópico(s)Pharmacological Effects of Natural Compounds
ResumoA cough model induced by sulfur dioxide gas was devised for use with mice. In this method, the ED50 of morphine hydrochloride was 1.58 mg/kg p. o. and that of codeine phosphate was 10.28 mg/kg p. o. Using the method established, L-ephedrine hydrochloride, 0.4, 4.0 and 40 mg/kg p. o., inhibited the cough induction in a dose-dependent manner and amygdalin, 1.0, 10 and 100 mg/kg p. o., also inhibited the cough induction. On the other hand, treatment of Makyokansekito, 162 mg/kg p. o., which contained Ephedrae herba (L-ephedrine, 4.6 mg/kg) and Armeniacae semen (amygdalin, 8.4 mg/kg) as component, showed stronger antitussive effects than the individual crude drugs.
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