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Synthetic Studies via Arene-Metal Compounds. An Application to the Regioselective Synthesis of a Natural Phthalide

1980; Oxford University Press; Volume: 53; Issue: 1 Linguagem: Inglês

10.1246/bcsj.53.293

1348-0634

Motokazu Uemura, Naomi Nishikawa, Satoru Tokuyama, Yasuhiko Hayashi,

Axial and Atropisomeric Chirality Synthesis

Abstract A naturally occuring methoxyphthalide derivative, a constituent of Othonna Cylindrica Dc, was synthesized by employing stereoselective carbonyl reduction of (η-arene)tricarbonylchromium complex and regioselective lithiation of 7-methoxy-2-(1-hydroxyethyl)-1-tetralol.