Molecular study of 45,X conceptuses: Correlation with clinical findings
1992; Wiley; Volume: 42; Issue: 4 Linguagem: Inglês
10.1002/ajmg.1320420414
ISSN1096-8628
AutoresIsabel Lorda‐Sánchez, Franz Binkert, Marco Maechler, Albert Schinzel,
Tópico(s)Prenatal Screening and Diagnostics
ResumoAbstract The parental origin of the single X in 45 cases (40 liveborns and 5 fetuses) with a 45, X karyo‐type was studied using polymorphic DNA probes. The single X was paternal in origin (X p ) in 10 cases (22.2%) and maternal (X m ) in 35 cases (77.8%). Y chromosome material was detected in 1 out of the 35 cases with a 45, X m constitution. Analysis of parental ages and clinical data of the patients with respect to the origin of the single X revealed no significant differences between the origins.
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