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C-Type Natriuretic Peptide and the Guanylyl Cyclase Receptors in the Rat Ovary are Modulated by the Estrous Cycle1

1997; Oxford University Press; Volume: 56; Issue: 1 Linguagem: Inglês

10.1095/biolreprod56.1.59

1529-7268

Marek Jankowski, Adelina M. Reis, Suhayla Mukaddam‐Daher, Than-Vinh Dam, Riaz Farookhi, Jolanta Gutkowska,

Blood Coagulation and Thrombosis Mechanisms

We have previously shown that rat ovaries synthesize atrial natriuretic peptide (ANP) and express the cognate guanylyl cyclase (GC-A and GC-B) receptors for ANP. Since another natriuretic peptide, termed the C-type natriuretic peptide (CNP), can also interact with these receptors, we have investigated whether rat ovaries express CNP and if so, whether the concentration of this natriuretic peptide and the guanylyl-cyclase receptors are influenced by the estrous cycle.