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Both HLA-B∗1301 and B∗1302 Exist in Asian Populations and Are Associated with Different Haplotypes

1995; Elsevier BV; Volume: 43; Issue: 1 Linguagem: Inglês

10.1016/0198-8859(94)00120-f

1879-1166

Ling Lin, Katsushi Tokunaga, Fumiaki Nakajima, Yoshihide Ishikawa, Kouichi Kashiwase, Hidenori Tanaka, Shoji Kuwata, Elena W. Sideltseva, Tatsuya Akaza, Kenji Tadokoro, Yoichi Shibata, Dasnayanee Chandanayingyong, Takeo Juji,

Parvovirus B19 Infection Studies

A B13 split antigen was newly identified with three alloantisera in Japanese, and two B13 split antigens were found in a Thai family. To confirm the variation of B13 and understand the correspondence between the serologic splits and the published B13 alleles, B∗1301 and B∗1302, we determined the sequences of genes coding for these B13 splits. The common Japanese B13 allele was found to be B∗ 1301, whereas another split antigen was shown to be coded by B∗1302. Two B13 variants identified in a Thai individual corresponded to B∗1301 and B∗1302. Moreover, 57 B13-positive samples from several ethnic groups were examined using the PCR-SSO method. Differing from previous reports, both B∗1301 and B∗1302 were found in samples from Asian populations. These two alleles were separately associated with different antigens: HLA-B∗1301 exhibited a strong association with A2, Cw10, DR12, and DQ7 antigens, whereas HLA-B∗1302 was strongly associated with A30, Cw6, DR7, and DQ2 antigens. In addition, applying the PCR-SSCP method, B∗1301 and B∗1302 could also be simply distinguished from each other.