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Bioactive Indole Alkaloids from the Bark of Uncaria guianensis

1999; Thieme Medical Publishers (Germany); Volume: 65; Issue: 08 Linguagem: Inglês

10.1055/s-2006-960860

1439-0221

Kit Lee, Bing‐Nan Zhou, David G. I. Kingston, Abraham Vaisberg, Gerald B. Hammond,

Traditional and Medicinal Uses of Annonaceae

Bioassay-guided fractionation of the EtOH extract of the bark of Uncaria guianensis (Aubl.) Cmel (Rubiaceae) using a yeast-based assay for DNA-damaging agents has furnished the two weakly but selectively active indole alkaloids uncarine C (1) and uncarine E (2) as the major bioactive constituents in this assay.