Effects of lindane on fluidity and lipid composition in rat renal cortex membranes
1991; Elsevier BV; Volume: 1066; Issue: 2 Linguagem: Inglês
10.1016/0005-2736(91)90178-b
ISSN1879-2642
AutoresMiguel A. Pérez-Albarsanz, Pilar López‐Aparicio, Sergio Senar, M.N. Recio,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoThe influence of lindane upon dynamic properties of plasma membranes from rat renal cortex has been investigated using a fluorescence polarization technique. Preincubation with lindane increased membrane fluidity in a manner that is dose-dependent. This increase was higher in brush border membranes than in basolateral membranes. However, a significant decrease of the membrane fluidity was found in brush border membranes when rats were injected with lindane for 12 days. A possible solution to this difference could involve a resistance to membrane disordering by lindane through a regulatory mechanism that would balance the amount of cholesterol and phospholipid classes in the renal cortex membranes of lindane-injected rats.
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