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Identification of Magnolol and Honokiol as Anxiolytic Agents in Extracts of Saiboku-to, an Oriental Herbal Medicine

1998; American Chemical Society; Volume: 61; Issue: 1 Linguagem: Inglês

10.1021/np9702446

1520-6025

Yūji Maruyama, Hisashi Kuribara, Makoto Morita, Mitsutoshi Yuzurihara, Susan T. Weintraub,

Oxidative Organic Chemistry Reactions

The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2-propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.