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BIBTEX RIS

Modulation of poly(ADP-ribosylation) in apoptotic cells

2004; Elsevier BV; Volume: 68; Issue: 6 Linguagem: Inglês

10.1016/j.bcp.2004.04.023

ISSN

1873-2968

Autores

A. Ivana Scovassi, Marc Diederich,

Tópico(s)

Cell death mechanisms and regulation

Resumo

Poly(ADP-ribosylation) is a post-translational modification of proteins playing a crucial role in DNA repair, replication, transcription and cell death. In this paper, the main features of this process have been reviewed, focusing on the best known poly(ADP-ribose) polymerizing enzyme, PARP-1, a DNA nick-sensor protein that uses β-NAD+ to form polymers of ADP-ribose. The modulation of poly(ADP-ribosylation) during apoptosis and the possible effects of its inhibition on cell metabolism are discussed.

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