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Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination

2013; Springer Science+Business Media; Volume: 158; Issue: 12 Linguagem: Inglês

10.1007/s00705-013-1754-z

1432-8798

Júlia Sarkadi, Máté Jankovics, Zoltán Kis, Jozsef Skare, Kinga Fodor, Éva Gönczöl, Ildikó Visontai, Zoltán Vajó, István Jankovics,

Animal Disease Management and Epidemiology

Chinese painted quails immunized with a single dose (6 μg HA) of inactivated H5N1 (clade 1) influenza vaccine NIBRG-14 and challenged with 100 LD50 of the heterologous A/Swan/Nagybaracska/01/06(H5N1) (clade 2.2) strain were protected, whereas unvaccinated quails died after challenge. No viral antigens or RNA were detected in cloacal swabs from immunized animals. Sera obtained post-immunization gave low titres in serological assays against the vaccine and the challenge viruses. Our results demonstrate the protective efficacy of the NIBRG-14 strain against the challenge virus and the usefulness of these small birds in protection studies of influenza vaccines.