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Artigo Revisado por pares
BIBTEX RIS

Effect of S-Adenosyl-L-Methionine (SAMe) upon depressive symptoms

1976; Elsevier BV; Volume: 13; Issue: 1 Linguagem: Inglês

10.1016/0022-3956(76)90008-x

ISSN

1879-1379

Autores

A. Agnoli, V.M. Andreoli, M Casacchia, R. Cerbo,

Tópico(s)

Amino Acid Enzymes and Metabolism

Resumo

SAMe is a methyl donor involved in methylation processes generally, including the Central Nervous System. Thirty depressed patients were studied in a double blind trial. The Hamilton Depression Rating Scale was used for symptom evaluation. The drug (45 mg i.m. daily) appeared to have a rapid and beneficial effect mainly upon depressed mood, suicidal tendencies, retardation and performance. Improvement was observed in 80% of the cases in 4–6 days. Studies are now in progress to clarify the biological mechanism involved in SAMe's antidepressive action.

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