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Untreated Chronic Myelocytic Leukemia Associated with an Unusual Chromosome Pattern

1964; American College of Physicians; Volume: 61; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-61-4-696

1539-3704

Elsie W. Houston,

Acute Myeloid Leukemia Research

Case Studies1 October 1964Untreated Chronic Myelocytic Leukemia Associated with an Unusual Chromosome PatternELSIE W. HOUSTON, M.SC., WILLIAM C. LEVIN, M.D., F.A.C.P., STEPHAN E. RITZMANN, M.D.ELSIE W. HOUSTON, M.SC.Search for more papers by this author, WILLIAM C. LEVIN, M.D., F.A.C.P.Search for more papers by this author, STEPHAN E. RITZMANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-696 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReports in the literature of various chromosomal abnormalities associated with leukemias continue to appear (1-9). The subject of this report is a white female patient with chronic myelocytic leukemia associated with an unusual chromosome pattern. Her clinical course has progressed very slowly and she has not as yet required treatment.CASE REPORTCLINICAL FINDINGSThe patient is a 48-year-old white female, with a 5-yr history of gastrointestinal distress upon the ingestion of certain foods. Diagnostic gastrointestinal X rays and two chest X rays performed within the 2-yr period preceding the onset of the present illness constitute the only known exposure...References1. FITZGERALD PH: Ph1 chromosome in uncultured leukocytes and marrow cells from human chronic granulocytic leukemia. Exp. Cell Res. 26: 220, 1962. CrossrefMedlineGoogle Scholar2. FITZGERALDADAMSGUNZ PHAFA: Chronic granulocytic leukemia and the Ph1 chromosome. Blood 21: 183, 1963. CrossrefMedlineGoogle Scholar3. NOWELLHUNGERFORD PCDA: Chromosome studies in human leukemia. II. Chronic granulocytic leukemia. J. Nat. Cancer Inst. 27: 1013, 1961. MedlineGoogle Scholar4. SANBERGISHIHARAMIWAHAUSCHKA AATTTS: In vivo chromosome constitution of marrow from 34 human leukemias and 60 non-leukemic controls. Cancer Res. 21: 678, 1961. MedlineGoogle Scholar5. TOUGHBAIKIEHARNDENKINGCOURT BROWNBUCKTONJACOBSMCBRIDE IAGDGMJWMKPAJA: Cytogenetic studies in chronic myeloid leukemia and acute leukemia associated with mongolism. Lancet 1: 411, 1961. CrossrefMedlineGoogle Scholar6. TOUGHBUCKTONBAIKIECOURT BROWN IKAGWM: X-ray induced chromosome damage in man. Lancet 2: 849, 1960. CrossrefMedlineGoogle Scholar7. TOUGHJACOBSCOURT BROWNBAIKIEWILLIAMSON IPAWMAGER: Cytogenetic studies on bone marrow in chronic myeloid leukemia. Lancet 1: 844, 1963. CrossrefMedlineGoogle Scholar8. WAHRMANROBINSON JE: Chromosome damage after x-ray therapy. Lancet 1: 505, 1963. CrossrefGoogle Scholar9. WAHRMANSCHAAPROBINSON JTE: Manifold chromosome abnormalities in leukemia. Lancet 1: 1098, 1962. CrossrefMedlineGoogle Scholar10. KAPLOW LS: A histochemical procedure for localizing and evaluating leukocyte alkaline phosphatase activity in smears of blood and marrow. Blood 10: 1023, 1955. CrossrefMedlineGoogle Scholar11. MOORHEADNOWELLMELLMANBATTIPSHUNGERFORD PSPCWJDMDA: Chromosome preparations of leukocytes cultured from human peripheral blood. Exp. Cell Res. 20: 613, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ELSIE W. HOUSTON, M.SC.; WILLIAM C. LEVIN, M.D., F.A.C.P.; STEPHAN E. RITZMANN, M.D.From the Department of Medicine and Hematology Research Laboratory, University of Texas Branch, Galveston, Texas.This work was aided in part by grant TI AM 5208-04 from the U. S. Public Health Service, Bethesda, Md., and a grant from the Brown-Lupton Foundation.Requests for reprints should be addressed to William C. Levin, M.D., Department of Internal Medicine, Room MW408, University of Texas Medical Branch, Galveston, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChromosomal Changes in Human Tumors and LeukemiasAspetti citogenetici della leucemia mieloide cronicaSystem Niob—Lithium—Sauerstoff?Epitheloidzellige Lymphogranulomatose? mit Gammopathie und ChromosomenaberrationenBIBLIOGRAPHYDas Philadelphia ChromosomCytogenetic analysis in two cases of lymphoma.Comparison between lymphosarcoma and reticulosarcomaChromosomentranslokation bei chronisch-myeloproliferativem SyndromPhiladelphia-Chromosom und alkalische Leukocyten-Phosphatase bei chronischer MyeloseDouble Ph1 chromosomes in chronic granulocytic leukemiaCoexistent chronic myelocytic leukemia, monoclonal gammopathy and multiple chromosomal abnormalities 1 October 1964Volume 61, Issue 4Page: 696-702KeywordsChromosomesChronic myelocytic leukemiaFoodHematology and oncologyIngestionKaryotypesLeukemiaMedical servicesResearch laboratoriesThorax ePublished: 1 December 2008 Issue Published: 1 October 1964 PDF downloadLoading ...