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Lectin from Crataeva tapia bark exerts antitumor, anti-inflammtory and analgesic activities

2011; Springer Science+Business Media; Volume: 1; Issue: 2 Linguagem: Inglês

10.1007/s13659-011-0014-8

2192-2195

Regina Maria Sousa de Araújo, Antônio Fernando de Melo Vaz, Jaciana dos Santos Aguiar, Luana Cassandra Breitenbach Barroso Coelho, Patrícia Maria Guedes Paiva, Ana Maria Mendonça de Albuquerque Melo, Teresinha Gonçalves da Silva, Maria Tereza dos Santos Correia,

Ethnobotanical and Medicinal Plants Studies

Crataeva tapia bark lectin was evaluated for its antitumor activity against sarcoma 180 in Swiss albino mice. The anti-inflammatory and analgesic properties were investigated in models of inflammation and nociception. The anti-inflammatory assay was induced by carrageenan induced peritonitis and the analgesic activity was induced by acetic acid-induced writhing response. The lectin presents low toxicity with a LD50 of 2,500 mg/kg body weight and significant antitumor activity causing inhibition of tumor growth. The lectin also promoted significant reduction (35.4%) in the number of neutrophil migration induced by carrageenan. Concerning its analgesic property, the lectin inhibits abdominal contractions induced by acetic acid. The current results revealed a lectin with significant antitumoral, anti-inflammatory and antinociceptive activities. Further investigations to unveil the exact mechanisms are needed.